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Thrombospondin-1 counteracts the p97 inhibitor CB-5083 in colon carcinoma cells
p97 has recently emerged as a therapeutic target for cancer due to its essential functions in protein homeostasis. CB-5083 is a first-in-class, potent and selective ATP-competitive p97 inhibitor that induces proteotoxic stress in cancer cells. Potential mechanisms regulating the sensitivity of cells...
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| Publicado no: | Cell Cycle |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7469669/ https://ncbi.nlm.nih.gov/pubmed/32423265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1754584 |
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