DDRE-11. DEVELOPMENT OF THE FIRST-IN-CLASS INHIBITOR OF CHD4 - SENSITIZING RESISTANT GLIOMAS

Glioblastoma is a lethal brain tumor with high recurrence rate. CHD4 overexpression, which drives resistance to DNA damage, is one of the major sources of recurrence. Since standard GBM treatments like radiation and temozolomide chemotherapy create DNA damage, inhibition of CHD4 offers a new therape...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Nurmemmedov, Elmar, Kesari, Santosh
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Drug Discovery, Drug Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651560/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.256
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