CB-5083, an inhibitor of P97, suppresses osteosarcoma growth and stem cell properties by altering protein homeostasis

Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, and its treatment still needs to be improved. Here, we assessed the antitumor ability of CB-5083, an oral inhibitor of P97, in osteosarcoma. MTT, colony formation, sphere formation, cell cycle and apoptosis ass...

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Detalhes bibliográficos
Publicado no:Am J Transl Res
Main Authors: Zhao, Zhiqiang, Wu, Mansi, Zhang, Xuelin, Jin, Qinglin, Wang, Yongqian, Zou, Changye, Huang, Gang, Yin, Junqiang, Xie, Xianbiao, Shen, Jingnan
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7344079/
https://ncbi.nlm.nih.gov/pubmed/32655822
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