CB-5083, an inhibitor of P97, suppresses osteosarcoma growth and stem cell properties by altering protein homeostasis

Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, and its treatment still needs to be improved. Here, we assessed the antitumor ability of CB-5083, an oral inhibitor of P97, in osteosarcoma. MTT, colony formation, sphere formation, cell cycle and apoptosis ass...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Am J Transl Res
Päätekijät: Zhao, Zhiqiang, Wu, Mansi, Zhang, Xuelin, Jin, Qinglin, Wang, Yongqian, Zou, Changye, Huang, Gang, Yin, Junqiang, Xie, Xianbiao, Shen, Jingnan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: e-Century Publishing Corporation 2020
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7344079/
https://ncbi.nlm.nih.gov/pubmed/32655822
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