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Targeting neurolysin in acute myeloid leukemia
We recently identified the mitochondrial peptidase, neurolysin (NLN), as a top hit in an acute myeloid leukemia (AML) viability screen. Using chemical and genetic approaches, we demonstrated that loss of NLN disrupted respiratory chain supercomplex assembly and impaired oxidative metabolism in AML....
Gardado en:
| Publicado en: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7469488/ https://ncbi.nlm.nih.gov/pubmed/32944624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1761243 |
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