Tyrosine Nitration Contributes to Nitric Oxide–Stimulated Degradation of CYP2B6

Human cytochrome P450 (P450) CYP2B6 undergoes nitric oxide (NO)-dependent proteasomal degradation in response to the NO donor dipropylenetriamine NONOate (DPTA) and biologic NO in HeLa and HuH7 cell lines. CYP2B6 is also downregulated by NO in primary human hepatocytes. We hypothesized that NO or de...

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Bibliografiska uppgifter
I publikationen:Mol Pharmacol
Huvudupphovsmän: Lee, Choon-myung, Wilderman, P. Ross, Park, Ji Won, Murphy, Thomas J., Morgan, Edward T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2020
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469253/
https://ncbi.nlm.nih.gov/pubmed/32817462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.120.000020
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