Tyrosine Nitration Contributes to Nitric Oxide–Stimulated Degradation of CYP2B6

Human cytochrome P450 (P450) CYP2B6 undergoes nitric oxide (NO)-dependent proteasomal degradation in response to the NO donor dipropylenetriamine NONOate (DPTA) and biologic NO in HeLa and HuH7 cell lines. CYP2B6 is also downregulated by NO in primary human hepatocytes. We hypothesized that NO or de...

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Gepubliceerd in:Mol Pharmacol
Hoofdauteurs: Lee, Choon-myung, Wilderman, P. Ross, Park, Ji Won, Murphy, Thomas J., Morgan, Edward T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469253/
https://ncbi.nlm.nih.gov/pubmed/32817462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.120.000020
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