Establishment of a Transformation Coupled in vitro End Joining Assay to Estimate Radiosensitivity in Tumor Cells

Here, we present a modified in vitro end-joining (EJ) assay to quantify EJ capacity, accuracy as well as pathway switch to alternative end-joining (Alt-EJ) or single strand annealing (SSA). A novel transformation assay was established to specifically measure circular repair products, which correlate...

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Udgivet i:Front Oncol
Main Authors: Degenhardt, Sarah, Dreffke, Kristin, Schötz, Urlike, Petersen, Cordula, Engenhart-Cabillic, Rita, Rothkamm, Kai, Dahm-Daphi, Jochen, Dikomey, Ekkehard, Mansour, Wael Yassin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468517/
https://ncbi.nlm.nih.gov/pubmed/32974177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01480
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