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Inhibitory Activity of Insulin on Aβ Aggregation Is Restricted Due to Binding Selectivity and Specificity to Polymorphic Aβ States

[Image: see text] Clinical trials of intranasal insulin treatment for Alzheimer’s patients have shown cognitive and memory improvement, but the effect of insulin has shown a limitation. It was suggested that insulin molecule binds to Aβ aggregates and impedes Aβ aggregation. Yet, the specific intera...

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Publié dans:ACS Chem Neurosci
Auteurs principaux: Baram, Michal, Miller, Yifat
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2020
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467570/
https://ncbi.nlm.nih.gov/pubmed/31899862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00645
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