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Synergistic Interactions between Repeats in Tau Protein and Aβ Amyloids May Be Responsible for Accelerated Aggregation via Polymorphic States

[Image: see text] Amyloid plaques and neurofibrillary tangles simultaneously accumulate in Alzheimer’s disease (AD). It is known that Aβ and tau exist together in the mitochondria; however, the interactions between Aβ oligomers and tau are controversial. Moreover, it is still unclear which specific...

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Main Authors: Miller, Yifat, Ma, Buyong, Nussinov, Ruth
格式: Artigo
語言:Inglês
出版: American Chemical Society 2011
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109766/
https://ncbi.nlm.nih.gov/pubmed/21506544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200400u
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