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Interactions between Aβ and mutated Tau lead to polymorphism and induce aggregation of Aβ-mutated tau oligomeric complexes.

One of the main hallmarks of the fronto-temporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) is the accumulation of neurofibrillary tangles in the brain as an outcome of the aggregation of mutated tau protein. This process occurs due to a number of genetic mutations in the MAPT gene...

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Bibliografische gegevens
Hoofdauteurs: Yoav Raz, Yifat Miller
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science (PLoS) 2013-01-01
Reeks:PLoS ONE
Online toegang:http://europepmc.org/articles/PMC3741189?pdf=render
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