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Interactions between Aβ and Mutated Tau Lead to Polymorphism and Induce Aggregation of Aβ-Mutated Tau Oligomeric Complexes

One of the main hallmarks of the fronto-temporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) is the accumulation of neurofibrillary tangles in the brain as an outcome of the aggregation of mutated tau protein. This process occurs due to a number of genetic mutations in the MAPT gene...

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Bibliografiske detaljer
Main Authors: Raz, Yoav, Miller, Yifat
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741189/
https://ncbi.nlm.nih.gov/pubmed/23951348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073303
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