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Identification and Quantification of Oxidation Products in Full-Length Biotherapeutic Antibodies by NMR Spectroscopy

[Image: see text] Therapeutic proteins are an indispensable class of drugs and often therapeutics of last resort. They are sensitive to oxidation, which is of critical concern, because it can affect drug safety and efficacy. Protein oxidation, with methionine and tryptophan as the most susceptible m...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Anal Chem
Κύριοι συγγραφείς: Hinterholzer, Arthur, Stanojlovic, Vesna, Regl, Christof, Huber, Christian G., Cabrele, Chiara, Schubert, Mario
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2020
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467420/
https://ncbi.nlm.nih.gov/pubmed/32530275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c00965
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