Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-β Oligomers

Abnormal folding and aggregation of the microtubule-associated protein, Tau, is a hallmark of several neurodegenerative disorders, including Alzheimer’s disease (AD). Although normal Tau is an intrinsically disordered protein, it does exhibit tertiary structure whereby the N- and C-termini are often...

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Vydáno v:J Alzheimers Dis
Hlavní autoři: Rudenko, Lauren K., Wallrabe, Horst, Periasamy, Ammasi, Siller, Karsten H., Svindrych, Zdenek, Seward, Matthew E., Best, Merci N., Bloom, George S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464573/
https://ncbi.nlm.nih.gov/pubmed/31524157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190226
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