Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity

Genetic activation of hedgehog/glioma‐associated oncogene homolog (HH/GLI) signaling causes basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an effective therapy of BCC, though the frequent developm...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Grund‐Gröschke, Sandra, Ortner, Daniela, Szenes‐Nagy, Antal B., Zaborsky, Nadja, Weiss, Richard, Neureiter, Daniel, Wipplinger, Martin, Risch, Angela, Hammerl, Peter, Greil, Richard, Sibilia, Maria, Gratz, Iris K., Stoitzner, Patrizia, Aberger, Fritz
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463314/
https://ncbi.nlm.nih.gov/pubmed/32615027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12758
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