Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients

Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric acute lymphoblastic leukemia. Recently, NUDT15 variants were identified as a major determinant of mercaptopurine intolerance. Two NUDT15 variants, c.36_37insGGAGTC and c.415C > T, are located on exons 1...

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Publicado en:Sci Rep
Autores principales: Yu, Chih-Hsiang, Chang, Ya-Hsuan, Wang, Der-Shiun, Jou, Shiann-Tarng, Lin, Chien-Yu, Lin, Kai-Hsin, Lu, Meng-Yao, Raghav, Lovely, Chang, Hsiu-Hao, Wu, Kang-Hsi, Chou, Shu-Wei, Ni, Yu-Ling, Lin, Dong-Tsamn, Lin, Shu-Wha, Chen, Hsuan-Yu, Yang, Yung-Li
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463237/
https://ncbi.nlm.nih.gov/pubmed/32873882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71468-y
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