Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients

Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric acute lymphoblastic leukemia. Recently, NUDT15 variants were identified as a major determinant of mercaptopurine intolerance. Two NUDT15 variants, c.36_37insGGAGTC and c.415C > T, are located on exons 1...

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Publicat a:Sci Rep
Autors principals: Yu, Chih-Hsiang, Chang, Ya-Hsuan, Wang, Der-Shiun, Jou, Shiann-Tarng, Lin, Chien-Yu, Lin, Kai-Hsin, Lu, Meng-Yao, Raghav, Lovely, Chang, Hsiu-Hao, Wu, Kang-Hsi, Chou, Shu-Wei, Ni, Yu-Ling, Lin, Dong-Tsamn, Lin, Shu-Wha, Chen, Hsuan-Yu, Yang, Yung-Li
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463237/
https://ncbi.nlm.nih.gov/pubmed/32873882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71468-y
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