Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients

Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric acute lymphoblastic leukemia. Recently, NUDT15 variants were identified as a major determinant of mercaptopurine intolerance. Two NUDT15 variants, c.36_37insGGAGTC and c.415C > T, are located on exons 1...

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發表在:Sci Rep
Main Authors: Yu, Chih-Hsiang, Chang, Ya-Hsuan, Wang, Der-Shiun, Jou, Shiann-Tarng, Lin, Chien-Yu, Lin, Kai-Hsin, Lu, Meng-Yao, Raghav, Lovely, Chang, Hsiu-Hao, Wu, Kang-Hsi, Chou, Shu-Wei, Ni, Yu-Ling, Lin, Dong-Tsamn, Lin, Shu-Wha, Chen, Hsuan-Yu, Yang, Yung-Li
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463237/
https://ncbi.nlm.nih.gov/pubmed/32873882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71468-y
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