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Sterol 14-α-demethylase is vital for mitochondrial functions and stress tolerance in Leishmania major
Sterol 14-α-demethylase (C14DM) is a key enzyme in the biosynthesis of sterols and the primary target of azoles. In Leishmania major, genetic or chemical inactivation of C14DM leads to accumulation of 14-methylated sterol intermediates and profound plasma membrane abnormalities including increased f...
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| Publicado no: | PLoS Pathog |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7462297/ https://ncbi.nlm.nih.gov/pubmed/32817704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008810 |
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