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Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization

Gap junction-mediated intercellular communication facilitates the circulation of ions, small molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap junction proteins, connexin46 (Cx46) and connexin50 (Cx50), cause cataracts in people and in mice. Studies in mouse mo...

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Foilsithe in:Int J Mol Sci
Main Authors: Berthoud, Viviana M., Gao, Junyuan, Minogue, Peter J., Jara, Oscar, Mathias, Richard T., Beyer, Eric C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461132/
https://ncbi.nlm.nih.gov/pubmed/32823750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21165822
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