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The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation

PURPOSE: Mutations in connexin50 (Cx50) and connexin46 (Cx46) cause cataracts. Because the expression of Cx46fs380 leads to decreased gap junctional coupling and formation of calcium precipitates, we studied Cx50D47A lenses to test whether Cx50 mutants also cause cataracts due to calcium precipitati...

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Detaylı Bibliyografya
Yayımlandı:Invest Ophthalmol Vis Sci
Asıl Yazarlar: Berthoud, Viviana M., Gao, Junyuan, Minogue, Peter J., Jara, Oscar, Mathias, Richard T., Beyer, Eric C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Association for Research in Vision and Ophthalmology 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534014/
https://ncbi.nlm.nih.gov/pubmed/31117126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.18-26459
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