Podocyte Integrin-β(3) and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy

BACKGROUND: Diabetic nephropathy (dNP), now the leading cause of ESKD, lacks efficient therapies. Coagulation protease–dependent signaling modulates dNP, in part via the G protein–coupled, protease-activated receptors (PARs). Specifically, the cytoprotective protease-activated protein C (aPC) protec...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Madhusudhan, Thati, Ghosh, Sanchita, Wang, Hongjie, Dong, Wei, Gupta, Dheerendra, Elwakiel, Ahmed, Stoyanov, Stoyan, Al-Dabet, Moh’d Mohanad, Krishnan, Shruthi, Biemann, Ronald, Nazir, Sumra, Zimmermann, Silke, Mathew, Akash, Gadi, Ihsan, Rana, Rajiv, Zeng-Brouwers, Jinyang, Moeller, Marcus J., Schaefer, Liliana, Esmon, Charles T., Kohli, Shrey, Reiser, Jochen, Rezaie, Alireza R., Ruf, Wolfram, Isermann, Berend
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7460917/
https://ncbi.nlm.nih.gov/pubmed/32709711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019111163
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