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Triggering of the cGAS-STING pathway in human plasmacytoid dendritic cells inhibits TLR9-mediated interferon production
Plasmacytoid dendritic cells (pDCs) are potent producers of type-I and type-III interferons (IFNs) and play a major role in antiviral immunity and autoimmune disorders. The innate sensing of nucleic acids remains the major initiating factor for IFN production by pDCs. Toll-like receptor (TLR)-mediat...
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| Udgivet i: | J Immunol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7460725/ https://ncbi.nlm.nih.gov/pubmed/32471881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800933 |
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