Human plasmacytoid dendritic cells elicit a Type I Interferon response by sensing DNA via the cGAS-STING signaling pathway

Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN) and are important for host defense by sensing microbial DNA via TLR9. pDCs also play a critical role in the pathogenesis of IFN-driven autoimmune diseases. Yet, this autoimmune reaction is caused by the recognition of...

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Publicado en:Eur J Immunol
Autores principales: Bode, Christian, Fox, Mario, Tewary, Poonam, Steinhagen, Almut, Ellerkmann, Richard K., Klinman, Dennis, Baumgarten, Georg, Hornung, Veit, Steinhagen, Folkert
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389263/
https://ncbi.nlm.nih.gov/pubmed/27125983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201546113
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