BETA DEFENSIN 2 AND 3 PROMOTE THE UPTAKE OF SELF OR CpG DNA, ENHANCE IFN-α PRODUCTION BY HUMAN PLASMACYTOID DENDRITIC CELLS AND PROMOTE INFLAMMATION

Alarmins are a group of structurally diverse host defense antimicrobial peptides that are important immune activators. Here we present a novel role of two potent alarmins, human beta defensin 2 and 3 (HBD2 and 3) in promoting IFN-α production by human plasmacytoid DCs (pDCs). We demonstrate that HBD...

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Udgivet i:J Immunol
Main Authors: Tewary, Poonam, dela Rosa, Gonzalo, Sharma, Neeraj, Rodriguez, Luis G, Tarasov, Sergey G, Howard, OM Zack, Shirota, Hidekazu, Steinhagen, Folkert, Klinman, Dennis M., Yang, De, Oppenheim, Joost J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433160/
https://ncbi.nlm.nih.gov/pubmed/23776172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201648
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