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MDM2-C Functions as an E3 Ubiquitin Ligase
BACKGROUND: Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that is over-expressed in many cancers and regulates target proteins through ubiquitination. Full-length MDM2 (MDM2-FL) is best known for targeting wild-type p53 for degradation by the proteasome, but the functions of the many splice...
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| Pubblicato in: | Cancer Manag Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Dove
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7457725/ https://ncbi.nlm.nih.gov/pubmed/32904724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S260943 |
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