MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activity v...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Kwon, Duk-Hwa, Eom, Gwang Hyeon, Ko, Jeong Hyeon, Shin, Sera, Joung, Hosouk, Choe, Nakwon, Nam, Yoon Seok, Min, Hyun-Ki, Kook, Taewon, Yoon, Somy, Kang, Wanseok, Kim, Yong Sook, Kim, Hyung Seok, Choi, Hyuck, Koh, Jeong-Tae, Kim, Nacksung, Ahn, Youngkeun, Cho, Hyun-Jai, Lee, In-Kyu, Park, Dong Ho, Suk, Kyoungho, Seo, Sang Beom, Wissing, Erin R., Mendrysa, Susan M., Nam, Kwang-Il, Kook, Hyun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740400/
https://ncbi.nlm.nih.gov/pubmed/26832969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10492
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker