MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activity v...

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Publicado no:Nat Commun
Main Authors: Kwon, Duk-Hwa, Eom, Gwang Hyeon, Ko, Jeong Hyeon, Shin, Sera, Joung, Hosouk, Choe, Nakwon, Nam, Yoon Seok, Min, Hyun-Ki, Kook, Taewon, Yoon, Somy, Kang, Wanseok, Kim, Yong Sook, Kim, Hyung Seok, Choi, Hyuck, Koh, Jeong-Tae, Kim, Nacksung, Ahn, Youngkeun, Cho, Hyun-Jai, Lee, In-Kyu, Park, Dong Ho, Suk, Kyoungho, Seo, Sang Beom, Wissing, Erin R., Mendrysa, Susan M., Nam, Kwang-Il, Kook, Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740400/
https://ncbi.nlm.nih.gov/pubmed/26832969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10492
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