DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer

Zebularine is a novel potent inhibitor of both cytidine deaminase and DNA methylation. We examined the effect of zebularine on mammary tumor growth in genetically engineered MMTV-PyMT transgenic mice that develop mammary tumors at 60 days of age with 100% penetrance. The MMTV-PyMT transgenic mice we...

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Udgivet i:Mol Cancer Ther
Main Authors: Chen, Min, Shabashvili, Daniel, Nawab, Akbar, Yang, Sherry X., Dyer, Lisa M., Brown, Kevin D., Hollingshead, Melinda, Hunter, Kent W., Kaye, Frederic J., Hochwald, Steven N., Marquez, Victor E., Steeg, Patricia, Zajac-Kaye, Maria
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457145/
https://ncbi.nlm.nih.gov/pubmed/22203734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0458
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