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Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine
In mammals DNA methylation occurs at position 5 of cytosine in a CpG context and regulates gene expression. It plays an important role in diseases and inhibitors of DNA methyltransferases (DNMTs)—the enzymes responsible for DNA methylation—are used in clinics for cancer therapy. The most potent inhi...
Tallennettuna:
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2927531/ https://ncbi.nlm.nih.gov/pubmed/20808780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012388 |
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