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Mechanistic Insights into the Allosteric Regulation of the Clr4 Protein Lysine Methyltransferase by Autoinhibition and Automethylation

Clr4 is a histone H3 lysine 9 methyltransferase in Schizosaccharomyces pombe that is essential for heterochromatin formation. Previous biochemical and structural studies have shown that Clr4 is in an autoinhibited state in which an autoregulatory loop (ARL) blocks the active site. Automethylation of...

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Pubblicato in:Int J Mol Sci
Autori principali: Khella, Mina S., Bröhm, Alexander, Weirich, Sara, Jeltsch, Albert
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700585/
https://ncbi.nlm.nih.gov/pubmed/33266419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228832
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