Impact of TREM2(R47H) variant on tau pathology–induced gliosis and neurodegeneration

Alzheimer’s disease (AD) is characterized by plaques containing amyloid-β (Aβ) and neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. Beyond tau and Aβ, evidence suggests that microglia play an important role in AD pathogenesis. Rare variants in the microglia-expressed triggeri...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Gratuze, Maud, Leyns, Cheryl E.G., Sauerbeck, Andrew D., St-Pierre, Marie-Kim, Xiong, Monica, Kim, Nayeon, Serrano, Javier Remolina, Tremblay, Marie-Ève, Kummer, Terrance T., Colonna, Marco, Ulrich, Jason D., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456230/
https://ncbi.nlm.nih.gov/pubmed/32544086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138179
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