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Physical modeling of the heritability and maintenance of epigenetic modifications

We develop a predictive theoretical model of the physical mechanisms that govern the heritability and maintenance of epigenetic modifications. This model focuses on a particular modification, methylation of lysine-9 of histone H3 (H3K9), which is one of the most representative and critical epigeneti...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Sandholtz, Sarah H., MacPherson, Quinn, Spakowitz, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456148/
https://ncbi.nlm.nih.gov/pubmed/32778583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920499117
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