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Bottom–up modeling of chromatin segregation due to epigenetic modifications
We use a chromosome-scale simulation to show that the preferential binding of heterochromatin protein 1 (HP1) to regions high in histone methylation (specifically H3K9me3) results in phase segregation and reproduces features of the observed Hi-C contact map. Specifically, we perform Monte Carlo simu...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6294944/ https://ncbi.nlm.nih.gov/pubmed/30478042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812268115 |
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