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Chromosome Structural Mechanics Dictates the Local Spreading of Epigenetic Marks

We present a theoretical model that demonstrates the integral role chromosome organization and structural mechanics play in the spreading of histone modifications involved in epigenetic regulation. Our model shows that heterogeneous nucleosome positioning, and the resulting position-dependent mechan...

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Bibliografiska uppgifter
I publikationen:Biophys J
Huvudupphovsmän: Sandholtz, Sarah H., Kannan, Deepti, Beltran, Bruno G., Spakowitz, Andrew J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642308/
https://ncbi.nlm.nih.gov/pubmed/33010237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.08.039
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