Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo

In autosomal dominant polycystic kidney disease (ADPKD) multiple bilateral renal cysts gradually enlarge, leading to a decline in renal function. Transepithelial chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1) are known to drive cyst en...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Cabrita, Ines, Kraus, Andre, Scholz, Julia Katharina, Skoczynski, Kathrin, Schreiber, Rainer, Kunzelmann, Karl, Buchholz, Björn
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455562/
https://ncbi.nlm.nih.gov/pubmed/32859916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18104-5
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