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Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A
BACKGROUND: Transepithelial chloride(−) secretion, through the chloride channels cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1), drives cyst enlargement in polycystic kidney disease (PKD). Polycystic kidneys are hypoxic, and oxidative stress activates TMEM16A. H...
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| Publicado no: | J Am Soc Nephrol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6362630/ https://ncbi.nlm.nih.gov/pubmed/30606785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018010039 |
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