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Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A
BACKGROUND: Transepithelial chloride(−) secretion, through the chloride channels cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1), drives cyst enlargement in polycystic kidney disease (PKD). Polycystic kidneys are hypoxic, and oxidative stress activates TMEM16A. H...
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| Udgivet i: | J Am Soc Nephrol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Nephrology
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6362630/ https://ncbi.nlm.nih.gov/pubmed/30606785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018010039 |
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