Pharmacological Inhibition and Activation of the Ca(2+) Activated Cl(−) Channel TMEM16A

TMEM16A is a Ca(2+) activated Cl(−) channel with important functions in airways, intestine, and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic fibrosis (CF) to reinstall airway Cl(−) secretion and to enhance airway surface liquid (ASL). This CFTR-agnostic approach...

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Bibliographic Details
Published in:	Int J Mol Sci
Main Authors:	Centeio, Raquel, Cabrita, Inês, Benedetto, Roberta, Talbi, Khaoula, Ousingsawat, Jiraporn, Schreiber, Rainer, Sullivan, John K., Kunzelmann, Karl
Format:	Artigo
Language:	Inglês
Published:	MDPI 2020
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7177308/ https://ncbi.nlm.nih.gov/pubmed/32272686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072557
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Pharmacological Inhibition and Activation of the Ca(2+) Activated Cl(−) Channel TMEM16A

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