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Pharmacological Inhibition and Activation of the Ca(2+) Activated Cl(−) Channel TMEM16A
TMEM16A is a Ca(2+) activated Cl(−) channel with important functions in airways, intestine, and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic fibrosis (CF) to reinstall airway Cl(−) secretion and to enhance airway surface liquid (ASL). This CFTR-agnostic approach...
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| Publicado no: | Int J Mol Sci |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7177308/ https://ncbi.nlm.nih.gov/pubmed/32272686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072557 |
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