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CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A

TMEM16A, a Ca(2+)-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a secreted protein with protease activity that was demonstrated to enhance membrane expression of TMEM16A. Expression of CLCA1 is partic...

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Podrobná bibliografie
Vydáno v:Int J Mol Sci
Hlavní autoři: Centeio, Raquel, Ousingsawat, Jiraporn, Schreiber, Rainer, Kunzelmann, Karl
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151571/
https://ncbi.nlm.nih.gov/pubmed/34066250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105133
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