Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling

Mutations in PKD1 (encoding for polycystin-1 [PC1]) are found in 80%–85% of patients with autosomal dominant polycystic kidney disease (ADPKD). We tested the hypothesis that changes in actin dynamics result from PKD1 mutations through dysregulation of compartmentalized centrosomal RhoA signaling med...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Streets, Andrew J., Prosseda, Philipp P., Ong, Albert C.M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455122/
https://ncbi.nlm.nih.gov/pubmed/32663194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135385
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