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RhoA and RhoC Are Both Required for the ROCK II-Dependent Promotion of Centrosome Duplication
CDK2-cyclin E triggers centrosome duplication, and nucleophosmin (NPM/B23) is found to be one of its targets. NPM/B23 phosphorylated by CDK2-cyclin E acquires a high binding affinity to Rho-associated kinase (ROCK II), and physically associates with ROCK II. The NPM/B23-binding results in super-acti...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978787/ https://ncbi.nlm.nih.gov/pubmed/20697357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.328 |
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