RhoA and RhoC Are Both Required for the ROCK II-Dependent Promotion of Centrosome Duplication

CDK2-cyclin E triggers centrosome duplication, and nucleophosmin (NPM/B23) is found to be one of its targets. NPM/B23 phosphorylated by CDK2-cyclin E acquires a high binding affinity to Rho-associated kinase (ROCK II), and physically associates with ROCK II. The NPM/B23-binding results in super-acti...

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Bibliografiske detaljer
Main Authors: Kanai, Masayuki, Crowe, Matthew S., Zheng, Yi, Vande Woude, George F., Fukasawa, Kenji
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978787/
https://ncbi.nlm.nih.gov/pubmed/20697357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.328
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