Cumulative deamidations of the major lens protein γS‐crystallin increase its aggregation during unfolding and oxidation

Age‐related lens cataract is the major cause of blindness worldwide. The mechanisms whereby crystallins, the predominant lens proteins, assemble into large aggregates that scatter light within the lens, and cause cataract, are poorly understood. Due to the lack of protein turnover in the lens, cryst...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Protein Sci
Prif Awduron: Vetter, Calvin J., Thorn, David C., Wheeler, Samuel G., Mundorff, Charlie C., Halverson, Kate A., Wales, Thomas E., Shinde, Ujwal P., Engen, John R., David, Larry L., Carver, John A., Lampi, Kirsten J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley & Sons, Inc. 2020
Pynciau:
Full‐Length Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454558/
https://ncbi.nlm.nih.gov/pubmed/32697405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3915
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg