Cumulative deamidations of the major lens protein γS‐crystallin increase its aggregation during unfolding and oxidation

Age‐related lens cataract is the major cause of blindness worldwide. The mechanisms whereby crystallins, the predominant lens proteins, assemble into large aggregates that scatter light within the lens, and cause cataract, are poorly understood. Due to the lack of protein turnover in the lens, cryst...

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Gepubliceerd in:Protein Sci
Hoofdauteurs: Vetter, Calvin J., Thorn, David C., Wheeler, Samuel G., Mundorff, Charlie C., Halverson, Kate A., Wales, Thomas E., Shinde, Ujwal P., Engen, John R., David, Larry L., Carver, John A., Lampi, Kirsten J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454558/
https://ncbi.nlm.nih.gov/pubmed/32697405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3915
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