Llwytho...

Deamidation destabilizes and triggers aggregation of a lens protein, βA3-crystallin

Protein aggregation is a hallmark of several neurodegenerative diseases and also of cataracts. The major proteins in the lens of the eye are crystallins, which accumulate throughout life and are extensively modified. Deamidation is the major modification in the lens during aging and cataracts. Among...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Takata, Takumi, Oxford, Julie T., Demeler, Borries, Lampi, Kirsten J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525517/
https://ncbi.nlm.nih.gov/pubmed/18567786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.035410.108
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