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Deamidation destabilizes and triggers aggregation of a lens protein, βA3-crystallin
Protein aggregation is a hallmark of several neurodegenerative diseases and also of cataracts. The major proteins in the lens of the eye are crystallins, which accumulate throughout life and are extensively modified. Deamidation is the major modification in the lens during aging and cataracts. Among...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525517/ https://ncbi.nlm.nih.gov/pubmed/18567786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.035410.108 |
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