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Regio- and Enantioselective Synthesis of Trifluoromethyl-Substituted Homoallylic α-Tertiary NH(2)-Amines by Reactions Facilitated by a Threonine-Based Boron-Containing Catalyst

A method for catalytic regio- and enantioselective synthesis of trifluoromethyl-substituted and aryl-, heteroaryl-, alkenyl-, and alkynyl-substituted homoallylic α-tertiary NH(2)-amines is introduced. Easy- to-synthesize and robust N-silyl ketimines are converted to NH-ketimines in situ, which then...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Fager, Diana C., Morrison, Ryan J., Hoveyda, Amir H.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454190/
https://ncbi.nlm.nih.gov/pubmed/32219997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202001184
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