Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in precapillary pulmonary arterioles

Patients with hereditary or acquired hemolytic anemias have a high risk of developing in situ thrombosis of the pulmonary vasculature. While pulmonary thrombosis is a major morbidity associated with hemolytic disorders, the etiological mechanism underlying hemolysis-induced pulmonary thrombosis rema...

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Udgivet i:JCI Insight
Main Authors: Brzoska, Tomasz, Vats, Ravi, Bennewitz, Margaret F., Tutuncuoglu, Egemen, Watkins, Simon C., Ragni, Margaret V., Neal, Matthew D., Gladwin, Mark T., Sundd, Prithu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453902/
https://ncbi.nlm.nih.gov/pubmed/32544100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139437
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