Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology

Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development of effective therapy. We, therefore, use single-cell RNA s...

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Pubblicato in:Cell Rep
Autori principali: Gillen, Austin E., Riemondy, Kent A., Amani, Vladimir, Griesinger, Andrea M., Gilani, Ahmed, Venkataraman, Sujatha, Madhavan, Krishna, Prince, Eric, Sanford, Bridget, Hankinson, Todd C., Handler, Michael H., Vibhakar, Rajeev, Jones, Ken L., Mitra, Siddhartha, Hesselberth, Jay R., Foreman, Nicholas K., Donson, Andrew M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452755/
https://ncbi.nlm.nih.gov/pubmed/32783945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108023
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