EPEN-26. NON-CANONICAL NF-κB SIGNALING DRIVES MESENCHYMAL EPENDYMAL CELL SUBPOPULATION IN PFA EPENDYMOMA

NF-κB signaling is a hallmark of PFA1 ependymoma. Loss of LDOC1, through epigenetic silencing, leads to constitutively active NF-κB signaling and chronic IL-6 secretion. In this study, we investigate the loss of LDOC1 within the PFA tumor clusters. Using our PFA scRNAseq database, in which there are...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Griesinger, Andrea, Harris, Faith, Donson, Andrew, Gillen, Austin, Riemondy, Kent, Venkataraman, Sujatha, Amani, Vladimir, Handler, Michael, Hankinson, Todd, Foreman, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Ependymoma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715852/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.163
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