DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice

Muscle denervation at the neuromuscular junction (NMJ), the essential synapse between motor neuron and skeletal muscle, is associated with age-related motor impairment. Therefore, improving muscle innervation at aged NMJs may be an effective therapeutic strategy for treating the impairment. We previ...

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Publicado no:iScience
Main Authors: Ueta, Ryo, Sugita, Satoshi, Minegishi, Yoshihiko, Shimotoyodome, Akira, Ota, Noriyasu, Ogiso, Noboru, Eguchi, Takahiro, Yamanashi, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452162/
https://ncbi.nlm.nih.gov/pubmed/32758427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101385
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